2. Molecular Mechanisms of Chronic Heart Failure.

Novel mechanisms of sympathetic regulation in chronic heart failure.

The idea that activation of the sympathetic nervous system is part and parcel of the apparent positive feedback cycle of cardiac deterioration in the setting of chronic heart failure (CHF) is not a new one. Several reviews have clearly summarized the evidence for this concept using both clinical data and information from experimental models.1–4 Evidence from both neural recordings and measureme...

Central Mechanisms of Abnormal Sympathoexcitation in Chronic Heart Failure

It has been recognized that the sympathetic nervous system is abnormally activated in chronic heart failure, and leads to further worsening chronic heart failure. In the treatment of chronic heart failure many clinical studies have already suggested that the inhibition of the abnormal sympathetic hyperactivity by beta blockers is beneficial. It has been classically considered that abnormal symp...

Molecular Mechanisms of Myocardial Hypertrophy and Heart Failure

Doxorubicin induced heart failure: Phenotype and molecular mechanisms

Long term survival of childhood cancers is now more than 70%. Anthracyclines, including doxorubicin, are some of the most efficacious anticancer drugs available. However, its use as a chemotherapeutic agent is severely hindered by its dose-limiting toxicities. Most notably observed is cardiotoxicity, but other organ systems are also degraded by doxorubicin use. Despite the years of its use and ...

Mechanisms of Heart Failure in Type 2 Diabetes Mellitus.

cardiovascular diseases. Over the last decade, we have significantly contributed to the development of important concepts in the field of insulin signal transduction and the molecular basis of regulation of gene expression and energy metabolism. Genetic studies in worm C. elegans indicated that the insulin/IGF-1 signaling pathway via PI-3kinase→protein kinase B/Akt→Forkhead transcription factor...